Sama Therapeutics uses artificial intelligence (AI) to improve the accuracy of diagnosing and treating mental health and other complex disorders. Our platform uses realistic AI avatars to conduct standardized clinical interviews and questionnaires to improve consistency in assessment data and support remote monitoring in both routine patient care and clinical trials. As patients interact with our AI avatars, the system automatically gathers objective, subtle voice and facial expression patterns recorded through regular cameras and microphones. These digital markers enhance the agent's assessments with non-verbal information clinicians would take into account without adding burden to participants.